Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes. The Journal of Biological Chemistry, vol. 287. 25, pp. 21303–21315. (2012)
Villota C, América Campos A, Soledad Vidaurre S, Oliveira-Cruz L, Boccardo E, Burzio V, Varas M, Villegas J, Villa L, Valenzuela PD, Socias M, Roberts S, Burzio L.O.
Background: Antisense mitochondrial ncRNAs are down-regulated during oncogenesis by unknown mechanisms.
Results: High risk HPV E2 oncogene induces down-regulation of the antisense transcripts. Additionally, E6 and E7 induce expression of a new sense mitochondrial ncRNA.
Conclusion: HPV oncogenes modulate expression of mitochondrial ncRNAs.
Significance: During non-viral oncogenesis, cellular factor(s), analogously to E2, could induce down-regulation of the antisense mitochondrial nc RNAs.