Currently browsing: “2014”

Histone lysine methylation and chromatin replication

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Rivera C., Gurard-Levin Z. A., Almouzni G., Loyola A. Histone lysine methylation and chromatin replication. Biochim. Biophys. Acta 1839(12):1433-1439 (2014)
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Role of the Androgen Receptor in Breast Cancer and Preclinical Analysis of Enzalutamide

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ABSTRACT: Introduction: The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast cancers that retain AR. However, controversy exists regarding the role of AR, particularly in ER + tumors. Enzalutamide, an AR inhibitor that impairs nuclear localization of AR, was […]

Cochrane DR, Bernales S, Jacobsen BM, Cittelly DM, Howe EN, D'Amato NC, Spoelstra NS, Edgerton SM, Jean A, Guerrero J, Gómez F, Medicherla S, Alfaro IE, McCullagh E, Jedlicka P, Torkko KC, Thor AD, Elias AD, Protter AA, Richer JK. Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res. 2014 Jan 22;16(1):R7. doi: 10.1186/bcr3599. PubMed PMID: 24451109; PubMed Central PMCID: PMC3978822.
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The dopaminergic system in autoimmune diseases. Frontiers in Immunology

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ABSTRACT: Bidirectional interactions between the immune and the nervous system sare of considerable interest both for deciphering their functioning and for designing novel therapeutic strategies. The past decade has brough taburs to finsights into the molecular mechanisms involvedin neuroimmune communications mediated by dopamine. Studies of dendritic cells (DCs) revealed that they express the whole machinery […]

Pacheco R., Contreras F. and Zouali M. The dopaminergic system in autoimmune diseases. Frontiers in Immunology. 5: 117. (2014)
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On the thermodynamics of carbon nanotube single-file water loading: free energy, energy and entropy calculations

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ABSTRACT: Single-file water chains confined in carbon nanotubes have been extensively studied using molecular dynamics simulations. Specifically, the pore loading process of periodic (6,6) and (5,5) single-walled carbon nanotubes was thermodynamically characterized by means of free-energy calculations at every loading state and compared to bulk water employing thermodynamic cycles. Long simulations of each end-state allowed […]

Garate J.A., Perez-Acle T., Oostenbrink C. On the thermodynamics of carbon nanotube single-file water loading: free energy, energy and entropy calculations. Phys Chem Chem Phys. 16(11):5119-5128. (2014)
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Human Papillomavirus and non-coding RNAs: from basics to diagnostic

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ABSTRACT: Human Papillomavirus (HPV) is the etiological agent of cervical cancer. Like other oncogenic viruses HPV encode oncoproteins and the role of HPV oncogenes in cellular immortalization and transformation has been extensively investigated. HPV E6 and E7 proteins disable tumor suppressors p53 and Rb and up-regulate telomerase, fundamental changes for cell immortalization. Another important step […]

Villota C., Cifuentes-Muñoz N., Burzio L.O. Human Papillomavirus and non-coding RNAs: from basics to diagnostic. (2014)
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