Profile
In our laboratory we study the role of purinergic signaling in the differentiation of CD8+ T lymphocytes, with the aim of promoting the development of new cellular immunotherapies against cancer. We have discovered that CD73, one of the enzymes that regulates the production of extracellular adenosine, reduces the cytotoxic potential of CD8+ T lymphocytes. However, CD73 also has a positive impact on the regulation of lymphocyte survival.
- Research Head: Dr. Daniela Sauma M
- Doctoral Students: Juan Saavedra Almarza, Solange Gouet, Violeta Kallens
- Master Students: Brian Parra, Moira García
- Undergraduate Students: Pilar Hörmann, Eva Rekus, Felipe Morales, José Corrales
- Research Assistants: Leonardo Vargas, Valeska Simon
- Post-doctoral Fellow: Dr. Sofía Hidalgo
- Sarah Núñez (Former undergraduate student and Ph.D. student). Head Researcher at FCV, Chile
- Felipe Flores Santibáñez (Former undergraduate student and Master student). PhD Student at Facultad de Medicina, UCH
- Dominique Fernández (Former undergraduate student and Master student). PhD Student at Facultad de Medicina, UCH
- Bárbara Cuadra (Former undergraduate student and Master student). Research assistant at UDD
- Pedro Briceño (Former Master student). Research assistant at UMayor
- Mariana Rosemblatt (Former PhD Student). Professor at USS.
National Collaborations
- Dr. María Rosa Bono (Universidad de Chile)
- Dr. Mario Rosemblatt (Fundacion Ciencia & Vida)
- Dr. Fabiola Osorio (Universidad de Chile)
- Dr. Victoria Guixé (Universidad de Chile)
- Dr. Verónica Palma (Universidad de Chile)
- Dr. Alvaro Lladser (Fundacion Ciencia & Vida)
- Alberto Martín (Universidad Mayor)
- Alvaro Elorza (Universidad Andres Bello)
- César Cárdenas (Universidad Mayor)
Internationals Collaborations
- Dr. Eduardo Villablanca (Karolinska Institutet)
- Dr. Paul Beavis (Peter MacCallum Cancer Centre)
Publications
Sarah Núñez, Juan José Sáez, Dominique Fernández, Felipe Flores-Santibañez, Karla Alvarez, Gabriela Tejón, Paulina Ruíz, Paula Maldonado, Yessia Hidalgo, Valeria Manríquez, María Rosa Bono, Mario Rosemblatt, Daniela Sauma. Type 17 T helper cells contribute to anti-tumor immunity and promote the recruitment of Th1 cells to the tumor. Immunology. 139, 61-71 (2013).
Carolina Moore, Gabriela Tejón, Camila Fuentes, Yessia Hidalgo, Maria Rosa Bono, Paula Maldonado, Ricardo Fernandez, Kathryn Wood, Juan Alberto Fierro, Mario Rosemblatt, Daniela Sauma and Andrew Bushell. Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection. Eur J Immunol. 45: 452-463 (2015).
María Rosa Bono, Dominique Fernández, Felipe Flores-Santibáñez, Mario Rosemblatt, Daniela Sauma. CD73 and CD39 ectonucleotidases in T cell differentiation: beyond immunosuppression. FEBS Letters. 589 (22): 3454-60 (2015).
Felipe Flores-Santibáñez, Dominique Fernández, Daniel Meza, Gabriela Tejón, Leonardo Vargas, Lorena Varela-Nallar, Sebastián Arredondo, Victoria Guixé, Mario Rosemblatt, María Rosa Bono, Daniela Sauma. CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells. Immunology, 146(4):582-94 (2015).
Dominique Fernández, Felipe Flores-Santibáñez, Jocelyn Neira, Francisco Osorio-Barrios, Gabriela Tejón, Sarah Nuñez, Yessia Hidalgo, Maria Jose Fuenzalida, Daniel Meza, Gonzalo Ureta, Alvaro Lladser, Rodrigo Pacheco, Claudio Acuña-Castillo, Victoria Guixé, Francisco J. Quintana, Maria Rosa Bono, Mario Rosemblatt, Daniela Sauma. Purinergic Signaling as a Regulator of Th17 cell Plasticity. Plos One, 20;11(6):e0157889. doi: 10.1371/journal.pone.0157889. (2016).
Maria Rosa Bono, Gabriela Tejon, Felipe Flores-Santibañez, Dominique Fernandez, Mario Rosemblatt, Daniela Sauma. Retinoic Acid as a Modulator of T Cell Immunity. Nutrients, 13;8(6). pii: E349. doi: 10.3390/nu8060349. (2016).
Felipe Flores-Santibáñez, Bárbara Cuadra, Dominique Fernández, Mariana Rosemblatt, Sarah Núñez, Pablo Cruz, Felipe Gálvez-Cancino, J.César Cárdenas, Alvaro Lladser, Mario Rosemblatt, María Rosa Bono and Daniela Sauma.In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo. Frontiers in Immunology. 9:209. doi: 10.3389/fimmu.2018.00209 (2018).
Elizabeth Rivas-Yáñez, Carlos Barrera-Avalos, Brian Parra-Tello, Pedro Briceño, Mariana V. Rosemblatt, Juan Saavedra-Almarza, Mario Rosemblatt, Claudio Acuña-Castillo, María Rosa Bono and Daniela Sauma. P2X7 receptor at the crossroads of T cell fate. Int. J. Mol. Sci. 2020, 21, 4937; doi:10.3390/ijms21144937
Briceño P, Rivas-Yañez E, Rosemblatt MV, Parra-Tello B, Farías P, Vargas L, Simon V, Cárdenas C, Lladser A, Salazar-Onfray F, Elorza AA, Rosemblatt M, Bono MR, Sauma D. CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity. Front Cell Dev Biol. 2021 Feb 18;9:638037. doi: 10.3389/fcell.2021.638037. PMID: 33681221; PMCID: PMC7930398.
Mariana V. Rosemblatt, Brian Parra-Tello, Pedro Briceño, Elizabeth Rivas-Yáñez, Suat Tucer, Juan Saavedra-Almarza, Pilar Hörmann, Brandon A. Martínez, Álvaro Lladser, Mario Rosemblatt, Caglar Cekic, María Rosa Bono and Daniela Sauma. Ecto-5’-Nucleotidase (CD73) regulates the survival of CD8+ T cells. Front Cell Dev Biol. 2021Apr 9; 647058. doi: 10.3389/fcell.2021.647058.
