Currently browsing: “Tumorigenesis”

The unfolded protein response during prostate cancer development

KEYWORDS:

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). The UPR promotes cell survival by adjusting ER protein folding capacity but if homeostasis cannot be reestablished, apoptosis is induced. The execution of life/death decisions is regulated by the three UPR branches (IRE1, PERK, ATF6) and their downstream effectors. Events […]

Yick-Lun A., De la Fuente E., Walter P., Shuman M., Bernales S. (2009). The unfolded protein response during prostate cancer development. Cancer Metastasis Rev., 28, 219–223. doi: 10.1007/s10555-008-9180-5
[↓] PDF [+] More Information