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MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

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ABSTRACT: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting Cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. METHODS: […]

Villablanca E. J., Wang S., De Calisto J., Gomes D. C. O., Kane M. A., Napoli J. L., Blaner W. S., Kagechika H., Blomhoff R., Rosemblatt M., Bono M. R., Von Andrian U. H. and Mora J. R. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of Dendritic cells. Gastroenterology 141, 176-185 (2011)
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