Currently browsing: “Mitochondria”

Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes

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ABSTRACT Background: Antisense mitochondrial ncRNAs are down-regulated during oncogenesis by unknown mechanisms. Results: High risk HPV E2 oncogene induces down-regulation of the antisense transcripts. Additionally, E6 and E7 induce expression of a new sense mitochondrial ncRNA. Conclusion: HPV oncogenes modulate expression of mitochondrial ncRNAs. Significance: During non-viral oncogenesis, cellular factor(s), analogously to E2, could induce […]

Villota C, América Campos A, Soledad Vidaurre S, Oliveira-Cruz L, Boccardo E, Burzio V, Varas M, Villegas J, Villa L, Valenzuela PD, Socias M, Roberts S, Burzio L.O. Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes. The Journal of Biological Chemistry, vol. 287. 25, pp. 21303–21315. (2012)
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The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma

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ABSTRACT Background: Cervical cancer is the third most common disease and the fourth leading cause of death in female’s worldwide. Treatment of this disease is successful when detection is at early neoplasic stages. Hence, multiple efforts have been pursued for early detection of cervical neoplasia. The aim of this study was to analyze the differential […]

Villegas J, Dadlan K, Ávila R, Villota C, Burzio V, López C, Socias M, Zapata L,Burzio L.O. The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma. Cancer Science & Therapy, S7 (2013).
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Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer

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ABSTRACT Background: Bladder cancer is a significant cause of morbidity and mortality with a high recurrence rate. Early detection of bladder cancer is essential in order to remove the tumor, to preserve the organ and to avoid metastasis. The aim of this study was to analyze the differential expression of mitochondrial non-coding RNAs (sense and […]

Rivas A, Burzio V, Landerer E, Borgna V, Gatica S, Ávila R, López C, Villota C, De la Fuente R, Echenique J, Burzio L.O.Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer. BMC Urology, 12:37 (2012)
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Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

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Protein-folding occurs in several intracellular locations including the endoplasmic reticulum and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery. Disruption of homeostasis and an accumulation of unfolded proteins trigger stress responses, or unfolded protein responses (UPR), in these organelles. These pathways signal to increase the […]

Bernales S., Morales M., McCullagh E. (2012). Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration. Frontiers in Aging Neuroscience, 4(5). doi: 10.3389/fnagi.2012.00005
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Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells

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ABSTRACT: Background. We have previously shown a differential expression of a family of mitochondrial ncRNAs in normal and cancer cells. Normal proliferating cells and cancer cells express the sense mitochondrial ncRNA (SncmtRNA). In addition, while normal proliferating cells express two antisense mitochondrial ncRNAs (ASncmtRNAs-1 and 2), these transcripts seem to be universally down-regulated in cancer cells. […]

Landerer E., Villegas J., Burzio A. V., Oliveira L., Villota C., López C., Restovic F., Martínez R., Castillo O. and Burzio L. O. Nuclear localization of the mitochindrial ncRNAs in normal and cancer cells. Cell. Oncol. 34, 297-305 (2011)
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