Currently browsing: “Mario Rosemblatt”
Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation
ABSTRACT: Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β’ and interleukin (IL) […]
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Differential regulation of notch ligands in dendritic cells upon interaction with T helper cells
ABSTRACT: The Notch signalling pathway has recently been linked to T helper 1 (Th1) / T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting cells. However, whether stimuli other than pathogen-derived factors are involved in the regulation of Notch ligand expression in dendritic cells […]
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MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells
ABSTRACT: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting Cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. METHODS: […]
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Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus
ABSTRACT: Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to antinuclear Ab production. To identify gene intervals within Nba2 that control the development of autoantibody-producing B cells […]
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Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells
ABSTRACT: It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the gut-associated homing receptor CCR9. Thus, effector T cells generated after coculture with mesenteric lymph node […]
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A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins
ABSTRACT: We report here the protective effect against piscirickettsiosis elicited in fish by a mixture of recombinant proteins. A comparative genomics strategy was used on a genomic library of Piscirickettsia salmonis in order to select optimal candidates for a recombinant subunit vaccine to protect fish from rickettsial septicaemia (SRS). Based on this information, 15 P. […]
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Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells
ABSTRACT: Whereas naive T cells migrate only to secondary lymphoid organs¹˒², activation by antigen confers to T cells the ability to home to non-lymphoid sites³˒⁴. Activated effector/memory T cells migrate preferentially to tissues that are connected to the secondary lymphoid organs where antigen was first encountered⁵⁻⁷. Thus, oral antigens induce effector/memory cells that express essential […]
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