Currently browsing: “Mario Rosemblatt”

Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation

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ABSTRACT: Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β’ and interleukin (IL) […]

Moore C., Fuentes C., Sauma D., Morales J., Bono M. R., Rosemblatt M. and Fierro J. A. Retinoic acid generates regulatory T cells in experimental transplantation. Transplant. Proc. 43 (6): 2334-2337 (2011)
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Differential regulation of notch ligands in dendritic cells upon interaction with T helper cells

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ABSTRACT: The Notch signalling pathway has recently been linked to T helper 1 (Th1) / T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting cells. However, whether stimuli other than pathogen-derived factors are involved in the regulation of Notch ligand expression in dendritic cells […]

Sauma D., Espejo P., Ramirez A., Fierro A., Rosemblatt M. and Bono M. R. Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells. Scand. J. Immunol. 74, 62-70 (2011)
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MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

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ABSTRACT: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting Cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. METHODS: […]

Villablanca E. J., Wang S., De Calisto J., Gomes D. C. O., Kane M. A., Napoli J. L., Blaner W. S., Kagechika H., Blomhoff R., Rosemblatt M., Bono M. R., Von Andrian U. H. and Mora J. R. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of Dendritic cells. Gastroenterology 141, 176-185 (2011)
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Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus

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ABSTRACT: Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to antinuclear Ab production. To identify gene intervals within Nba2 that control the development of autoantibody-producing B cells […]

Jorgensen T. N., Alfaro J., Enriquez H. L., Jiang C., Loo W. M., Atencio S., Bupp M. R., Mailloux C. M., Metzger T., Flannery S., Rozzo S. J., Kotzin B. L., Rosemblatt M., Bono M. R. and Erickson L. D. Development of murine lupus involves the combined genetic contribution of the SLAM and FcyR intervals within the Nba2 autoimmune susceptibility locus. The J. Immunol. 15, 775-786 (2010)
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Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells

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ABSTRACT: It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the gut-associated homing receptor CCR9. Thus, effector T cells generated after coculture with mesenteric lymph node […]

Elgueta R., Sepúlveda F. E., Vilches F., Vargas L., Mora J. R., Bono M. R. and Rosemblatt M. Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells. J. Immunol. 180, 6501-6507 (2008)
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A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins

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ABSTRACT: We report here the protective effect against piscirickettsiosis elicited in fish by a mixture of recombinant proteins. A comparative genomics strategy was used on a genomic library of Piscirickettsia salmonis in order to select optimal candidates for a recombinant subunit vaccine to protect fish from rickettsial septicaemia (SRS). Based on this information, 15 P. […]

Wilhelm V., Miquel A., Burzio L. O., Rosemblatt M., Engel E., Valenzuela S, Parada G. and Valenzuela P. D. T. A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins. Vaccine 24 (23): 5083-5091 (2006)
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Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells

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ABSTRACT: Whereas naive T cells migrate only to secondary lymphoid organs¹˒², activation by antigen confers to T cells the ability to home to non-lymphoid sites³˒⁴. Activated effector/memory T cells migrate preferentially to tissues that are connected to the secondary lymphoid organs where antigen was first encountered⁵⁻⁷. Thus, oral antigens induce effector/memory cells that express essential […]

Mora J. R., Bono M. R., Manjunath N., Weninger W., Cavanagh L. L., Rosemblatt M. and Von Andrian U. H. Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells. Nature 424, 88-93 (2003)
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