Currently browsing: “Laboratory of Neuroimmunology”

Host immunity during Respiratory Syncytial Virus pathogenesis

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ABSTRACT: Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during […]

Bueno S. M., Gonzalez P. A., Pacheco R., Leiva E. D., Cautivo K. M., Tobar H. E., Mora J. E., Prado C. E., Zúñiga J. P., Jiménez J., Ferrés M., Riedel C. A., Kalergis A. M. (2008). Host Immunity during Respiratory Syncytial Virus pathogenesis. International Immunopharmacology. 8(10):1320-1329.
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Enzymatic and Extraenzymatic Role of Adenosine Deaminase 1 in T-Cell–Dendritic Cell Contacts and in Alterations of the Immune Function

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ABSTRACT: Adenosine deaminase 1 (ADA1) is an enzyme of the purine metabolism whose congenital defect leads to severe combined immunodeficiency (SCID)[[AU: OK?]]. Although classically considered a cytosolic enzyme, early evidence from work in brain synaptosomes suggested that the enzyme could be an ectoenzyme. In lymphoid cells, ectoenzymatic activity of ADA1 was also found. The obvious […]

Franco R., Pacheco R., Gatell J. M., Gallart T., Lluis C. (2007). Enzymatic and extra-enzymatic role of adenosine deaminase 1 in T cell-dendritic cell contacts and in alterations of the immune function. Crit Rev Immunol. 27(6):495-509.
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Role of CD26-adenosine deaminase interaction in the T cell-mediated immunity

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ABSTRACT: CD26 is a 110 kDa surface-bound ectopeptidase with intrinsic dipeptidyl peptidase IV (DPP IV) activity, which binds ade- nosine deaminase (ADA) on the surface of T cells. ADA is an enzyme of the purine metabolism that has been the object of consi- derable interest mainly because the congenital defect causes severe combined immunodeficiency (SCID). […]

Pacheco R., Lluis C., Franco R. (2005). Role of CD26-adenosine deaminase interaction in the T cell-mediated immunity. Inmunología, 24(2): 235-45.
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Hemocyanin of the molluskan concholepas concholepas exhibits an unusual heterodecameric array of subunits

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ABSTRACT: We describe here the structure of the hemocyanin from the Chilean gastropod Concholepas concholepas (CCH), emphasizing some attributes that make it interesting among molluscan hemocyanins. CCH exhibits a predominant didecameric structure as revealed by electron microscopy and a size of 8 MDa by gel filtration, and, in contrast with other mollusc hemocyanins, its stabilization […]

De Ioannes P., Moltedo B., Oliva H., Pacheco R., Faunes F., De Ioannes A.E., Becker M.I. (2004). Hemocyanin of the molluskan concholepas concholepas exhibits an unusual heterodecameric array of subunits. J Biol Chem, 279(25):26134-42.
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Immune complex-induced enhancement of bacterial antigen presentation requires FcУ Receptor III expression on dendritic cells

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ABSTRACT: Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious agents by presenting pathogen- derived antigens on MHC molecules to naïve T cells. Because of their key role in priming adaptive immunity, it is expected that interfering with DC function would be advantageous to the pathogen. We have previously shown that Salmonella […]

Herrada A. A., Contreras F. J., Tobar J. A., Pacheco R. and Kalergis A. M. Immune complex-induced enhancement of bacterial antigen presentation requires FcУ Receptor III expression on dendritic cells. PNAS 104 (33): 13402-13407 (2007)
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The emergence of neurotransmitters as immune modulators

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ABSTRACT: Initially, the idea that neurotransmitters could serve as immunomodulators emerged with the discovery that their release and diffusion from nervous tissue could lead to signaling through lymphocyte cell-surface receptors and the modulation of immune function. It is now evident that neurotransmitters can also be released from leukocytes and act as autocrine or paracrine modulators. […]

Franco R., Pacheco R., Lluis C., Ahern G. P. and O’Connell P. J. The emergence of neurotransmitters as immune modulators. Trends Immunol. 28 (9): 400-407 (2007)
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Role of glutamate on T-cell mediated immunity

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ABSTRACT: The pivotal role that glutamate plays in the functioning of the central nervous system is well established. Several glutamate receptors and glutamate transporters have been extensively described in the central nervous system where they, respectively mediate glutamate effects and regulates extracellular glutamate levels. Recent studies have shown that glutamate not only has a role […]

Pacheco R., Gallart T., Lluis C. and Franco R. Role of glutamate on T-cell mediated immunity. J. Neuroimmunol. 185 (1-2): 09-19 (2007)
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