Currently browsing: “Immune Response”

Host immunity during Respiratory Syncytial Virus pathogenesis


ABSTRACT: Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during […]

Bueno S. M., Gonzalez P. A., Pacheco R., Leiva E. D., Cautivo K. M., Tobar H. E., Mora J. E., Prado C. E., Zúñiga J. P., Jiménez J., Ferrés M., Riedel C. A., Kalergis A. M. (2008). Host Immunity during Respiratory Syncytial Virus pathogenesis. International Immunopharmacology. 8(10):1320-1329.
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MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells


ABSTRACT: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting Cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. METHODS: […]

Villablanca E. J., Wang S., De Calisto J., Gomes D. C. O., Kane M. A., Napoli J. L., Blaner W. S., Kagechika H., Blomhoff R., Rosemblatt M., Bono M. R., Von Andrian U. H. and Mora J. R. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of Dendritic cells. Gastroenterology 141, 176-185 (2011)
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