Currently browsing: “Cancer”

Human Papillomavirus and non-coding RNAs: from basics to diagnostic

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ABSTRACT: Human Papillomavirus (HPV) is the etiological agent of cervical cancer. Like other oncogenic viruses HPV encode oncoproteins and the role of HPV oncogenes in cellular immortalization and transformation has been extensively investigated. HPV E6 and E7 proteins disable tumor suppressors p53 and Rb and up-regulate telomerase, fundamental changes for cell immortalization. Another important step […]

Villota C., Cifuentes-Muñoz N., Burzio L.O. Human Papillomavirus and non-coding RNAs: from basics to diagnostic. (2014)
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The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma

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ABSTRACT Background: Cervical cancer is the third most common disease and the fourth leading cause of death in female’s worldwide. Treatment of this disease is successful when detection is at early neoplasic stages. Hence, multiple efforts have been pursued for early detection of cervical neoplasia. The aim of this study was to analyze the differential […]

Villegas J, Dadlan K, Ávila R, Villota C, Burzio V, López C, Socias M, Zapata L,Burzio L.O. The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma. Cancer Science & Therapy, S7 (2013).
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Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer

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ABSTRACT Background: Bladder cancer is a significant cause of morbidity and mortality with a high recurrence rate. Early detection of bladder cancer is essential in order to remove the tumor, to preserve the organ and to avoid metastasis. The aim of this study was to analyze the differential expression of mitochondrial non-coding RNAs (sense and […]

Rivas A, Burzio V, Landerer E, Borgna V, Gatica S, Ávila R, López C, Villota C, De la Fuente R, Echenique J, Burzio L.O.Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer. BMC Urology, 12:37 (2012)
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Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells

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ABSTRACT: Background. We have previously shown a differential expression of a family of mitochondrial ncRNAs in normal and cancer cells. Normal proliferating cells and cancer cells express the sense mitochondrial ncRNA (SncmtRNA). In addition, while normal proliferating cells express two antisense mitochondrial ncRNAs (ASncmtRNAs-1 and 2), these transcripts seem to be universally down-regulated in cancer cells. […]

Landerer E., Villegas J., Burzio A. V., Oliveira L., Villota C., López C., Restovic F., Martínez R., Castillo O. and Burzio L. O. Nuclear localization of the mitochindrial ncRNAs in normal and cancer cells. Cell. Oncol. 34, 297-305 (2011)
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