Currently browsing: “Alzheimer’s disease”

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

KEYWORDS:

Protein-folding occurs in several intracellular locations including the endoplasmic reticulum and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery. Disruption of homeostasis and an accumulation of unfolded proteins trigger stress responses, or unfolded protein responses (UPR), in these organelles. These pathways signal to increase the […]

Bernales S., Morales M., McCullagh E. (2012). Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration. Frontiers in Aging Neuroscience, 4(5). doi: 10.3389/fnagi.2012.00005
[↓] PDF [+] More Information