Currently browsing: “2013”

Molecular characterization of a novel Na+/H+ antiporter cDNA from Eucalyptus globulus

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ABSTRACT: Environmental stress factors such as salt, drought and heat are known to affect plant productivity. However, high salinity is spreading throughout the world, currently affecting more than 45 million ha. One of the mechanisms that allow plants to withstand salt stress consists on vacuolar sequestration of Na+, through a Na+/H+ antiporter. We isolated a […]

Baltierra F., Castillo M., Gamboa M.C., Rothhammer M., Krauskopf E. Molecular characterization of a novel Na+/H+ antiporter cDNA from Eucalyptus globulus. Biochemical and Biophysical Research Communications. 430(2): 535-540 [corresponding author] (2013)
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In refererence to WKA Young

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Krauskopf E. In refererence to WKA Young. Neuro-Oncology. 15(2): 148 [corresponding author] (2013)
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Standardization of the institutional address

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Krauskopf E. Standardization of the institutional address. Scientometrics 94(3): 1313-1315[corresponding author] (2013)
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Deceivement of the research community through manipulation of the impact factor

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Krauskopf E. Deceivement of the research community through manipulation of the impact factor. Journal of the American Society for Information Science and Technology. 64(11):2403 [corresponding author] (2013)
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Drought and salt tolerance of transgenic Arabidopsis by overexpression of the vacuolar pyrophosphatase 1 (EVP1) gene from Eucalyptus globulus

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ABSTRACT: Vacuolar solute accumulation has been shown to be a mechanism by which plants are capable of increasing drought and salt tolerance. The exposure of plants to NaCl induces Hþ transport into the vacuole by specialized pumps. One of them corresponds to the vacuolar Hþ-pyrophosphatase, which generates a Hþ gradient across the vacuolar membrane. In […]

Gamboa M.C., Baltierra F., Leon G., Krauskopf E. Drought and salt tolerance of transgenic Arabidopsis by overexpression of the vacuolar pyrophosphatase 1 (EVP1) gene from Eucalyptus globulus. Plant Physiology and Biochemistry. 73: 99-105 [corresponding author] (2013)
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Trichostatin A promotes the generation and suppressive functions of regulatory T cells

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Abstract: Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through differentiation of na¨ıve CD4+ T cells. The forkhead box P3 transcription factor (Foxp3) is a crucial molecule […]

Doñas C., Fritz M., Manríquez V., Tejón G., Bono M. R., Loyola A., Rosemblatt M. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin. Dev. Immunol 2013, 679804 (2013)
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The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma

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ABSTRACT Background: Cervical cancer is the third most common disease and the fourth leading cause of death in female’s worldwide. Treatment of this disease is successful when detection is at early neoplasic stages. Hence, multiple efforts have been pursued for early detection of cervical neoplasia. The aim of this study was to analyze the differential […]

Villegas J, Dadlan K, Ávila R, Villota C, Burzio V, López C, Socias M, Zapata L,Burzio L.O. The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma. Cancer Science & Therapy, S7 (2013).
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Dopamine receptor D3 expressed on CD4+ T-cells favours neurodegeneration of dopaminergic neurons during Parkinson’s disease

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ABSTRACT: Emerging evidence has demonstrated that CD4+ T cells infiltrate into the substantia nigra (SN) in Parkinson’s disease (PD) patients and in animal models of PD. SN-infiltrated CD4+ T cells bearing inflammatory phenotypes promote microglial activation and strongly contribute to neurodegeneration of dopaminergic neurons. Importantly, altered expression of dopamine receptor D3 (D3R) in PBLs from […]

González H., Contreras F., Prado C., Elgueta D., Franz D., Bernales S. and Pacheco R. Dopamine receptor D3 expressed on CD4+ T-cells favours neurodegeneration of dopaminergic neurons during Parkinson's disease. Journal of Immunology. 190(10):5048-5056. (2013)
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Modulation of T-cell mediated immunity by dopamine receptor D5

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ABSTRACT: CD4+ T-cells are central players orchestrating antigen-specific immunity and tolerance. Importantly, dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate functional cells. Because of their fundamental roles in controlling immunity, activation and differentiation of DCs and CD4+ T-cells require tight regulatory mechanisms. Several studies have […]

Prado C., Bernales S. and Pacheco R. Modulation of T-cell mediated immunity by dopamine receptor D5. Endocrine, Metabolic & Immune Disorders-Drug Target. 13(2):184-194. (2013)
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Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer

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ABSTRACT: Background: Enzalutamide (formerly MDV3100 and available commercially as Xtandi®), a novel androgen receptor (AR) signaling inhibitor, blocks the growth of castration-resistant prostate cancer (CRPC) in cellular model systems and was shown in a clinical study to increase survival in patients with metastatic CRPC. Enzalutamide inhibits multiple steps of AR signaling: binding of androgens to […]

Guerrero J, Alfaro IE, Gómez F, Protter AA, Bernales S. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep;73(12):1291-305. doi:10.1002/pros.22674. Epub 2013 Jun 13. PubMed PMID: 23765603.
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