Currently browsing: “2011”

Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells

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ABSTRACT: Background. We have previously shown a differential expression of a family of mitochondrial ncRNAs in normal and cancer cells. Normal proliferating cells and cancer cells express the sense mitochondrial ncRNA (SncmtRNA). In addition, while normal proliferating cells express two antisense mitochondrial ncRNAs (ASncmtRNAs-1 and 2), these transcripts seem to be universally down-regulated in cancer cells. […]

Landerer E., Villegas J., Burzio A. V., Oliveira L., Villota C., López C., Restovic F., Martínez R., Castillo O. and Burzio L. O. Nuclear localization of the mitochindrial ncRNAs in normal and cancer cells. Cell. Oncol. 34, 297-305 (2011)
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Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation

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ABSTRACT: Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β’ and interleukin (IL) […]

Moore C., Fuentes C., Sauma D., Morales J., Bono M. R., Rosemblatt M. and Fierro J. A. Retinoic acid generates regulatory T cells in experimental transplantation. Transplant. Proc. 43 (6): 2334-2337 (2011)
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Differential regulation of notch ligands in dendritic cells upon interaction with T helper cells

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ABSTRACT: The Notch signalling pathway has recently been linked to T helper 1 (Th1) / T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting cells. However, whether stimuli other than pathogen-derived factors are involved in the regulation of Notch ligand expression in dendritic cells […]

Sauma D., Espejo P., Ramirez A., Fierro A., Rosemblatt M. and Bono M. R. Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells. Scand. J. Immunol. 74, 62-70 (2011)
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MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

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ABSTRACT: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting Cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. METHODS: […]

Villablanca E. J., Wang S., De Calisto J., Gomes D. C. O., Kane M. A., Napoli J. L., Blaner W. S., Kagechika H., Blomhoff R., Rosemblatt M., Bono M. R., Von Andrian U. H. and Mora J. R. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of Dendritic cells. Gastroenterology 141, 176-185 (2011)
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