Currently browsing: “2008”

Host immunity during Respiratory Syncytial Virus pathogenesis

KEYWORDS: 2008 • Dendritic cells • Immune Response • Laboratory of Neuroimmunology • Rodrigo Pacheco • T cells

ABSTRACT: Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during […]

Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells

KEYWORDS: 2008 • Laboratory of Cellular and Molecular Immunology • Mario Rosemblatt

ABSTRACT: It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the gut-associated homing receptor CCR9. Thus, effector T cells generated after coculture with mesenteric lymph node […]

Immune complex-induced enhancement of bacterial antigen presentation requires FcУ Receptor III expression on dendritic cells

KEYWORDS: 2008 • Antigen-presenting cells • Fc? Receptor • Laboratory of Neuroimmunology • phosphoinositide-3 kinase • Rodrigo Pacheco • Salmonella Typhimurium • T cells

ABSTRACT: Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious agents by presenting pathogen- derived antigens on MHC molecules to naïve T cells. Because of their key role in priming adaptive immunity, it is expected that interfering with DC function would be advantageous to the pathogen. We have previously shown that Salmonella […]