Currently browsing: “2008”

Host immunity during Respiratory Syncytial Virus pathogenesis

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ABSTRACT: Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during […]

Bueno S. M., Gonzalez P. A., Pacheco R., Leiva E. D., Cautivo K. M., Tobar H. E., Mora J. E., Prado C. E., Zúñiga J. P., Jiménez J., Ferrés M., Riedel C. A., Kalergis A. M. (2008). Host Immunity during Respiratory Syncytial Virus pathogenesis. International Immunopharmacology. 8(10):1320-1329.
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Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells

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ABSTRACT: It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the gut-associated homing receptor CCR9. Thus, effector T cells generated after coculture with mesenteric lymph node […]

Elgueta R., Sepúlveda F. E., Vilches F., Vargas L., Mora J. R., Bono M. R. and Rosemblatt M. Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells. J. Immunol. 180, 6501-6507 (2008)
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Immune complex-induced enhancement of bacterial antigen presentation requires FcУ Receptor III expression on dendritic cells

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ABSTRACT: Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious agents by presenting pathogen- derived antigens on MHC molecules to naïve T cells. Because of their key role in priming adaptive immunity, it is expected that interfering with DC function would be advantageous to the pathogen. We have previously shown that Salmonella […]

Herrada A. A., Contreras F. J., Tobar J. A., Pacheco R. and Kalergis A. M. Immune complex-induced enhancement of bacterial antigen presentation requires FcУ Receptor III expression on dendritic cells. PNAS 104 (33): 13402-13407 (2007)
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