Currently browsing: “2007”

Enzymatic and Extraenzymatic Role of Adenosine Deaminase 1 in T-Cell–Dendritic Cell Contacts and in Alterations of the Immune Function

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ABSTRACT: Adenosine deaminase 1 (ADA1) is an enzyme of the purine metabolism whose congenital defect leads to severe combined immunodeficiency (SCID)[[AU: OK?]]. Although classically considered a cytosolic enzyme, early evidence from work in brain synaptosomes suggested that the enzyme could be an ectoenzyme. In lymphoid cells, ectoenzymatic activity of ADA1 was also found. The obvious […]

Franco R., Pacheco R., Gatell J. M., Gallart T., Lluis C. (2007). Enzymatic and extra-enzymatic role of adenosine deaminase 1 in T cell-dendritic cell contacts and in alterations of the immune function. Crit Rev Immunol. 27(6):495-509.
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Low awareness of the link between science and innovation affects public policies in developing countries: The Chilean case

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ABSTRACT: Developing countries share disbelief about the benefits of the endogenous production of science as a tool for economical growth. Hence, public policies to strengthen science and technology and promote the culture of innovation are, in general, weak and sometimes incoherent. Patenting has become not only an icon to protect discoveries which can yield profits […]

Krauskopf M., Krauskopf E. and Méndez B. Low awareness of the link between science and innovation affects public policies in developing countries: The Chilean case. Scientometrics 72 (01): 93-103 (2007)
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Marking Histone H3 Variants: How, when and why?

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ABSTRACT: DNA in eukaryotic cells is compacted into chromatin, a regular repeated structure in which the nucleosome represents the basic unit. The nucleosome not only serves to compact the genetic material but also provides information that affects nuclear functions including DNA replication, repair and transcription. This information is conveyed through numerous combinations of histone post-translational […]

Loyola A., Almouzni G. Marking histone H3 variants: How, when and why?. Trends Biochem. Sci. 32(09): 425-433 (2007)
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The emergence of neurotransmitters as immune modulators

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ABSTRACT: Initially, the idea that neurotransmitters could serve as immunomodulators emerged with the discovery that their release and diffusion from nervous tissue could lead to signaling through lymphocyte cell-surface receptors and the modulation of immune function. It is now evident that neurotransmitters can also be released from leukocytes and act as autocrine or paracrine modulators. […]

Franco R., Pacheco R., Lluis C., Ahern G. P. and O’Connell P. J. The emergence of neurotransmitters as immune modulators. Trends Immunol. 28 (9): 400-407 (2007)
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Role of glutamate on T-cell mediated immunity

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ABSTRACT: The pivotal role that glutamate plays in the functioning of the central nervous system is well established. Several glutamate receptors and glutamate transporters have been extensively described in the central nervous system where they, respectively mediate glutamate effects and regulates extracellular glutamate levels. Recent studies have shown that glutamate not only has a role […]

Pacheco R., Gallart T., Lluis C. and Franco R. Role of glutamate on T-cell mediated immunity. J. Neuroimmunol. 185 (1-2): 09-19 (2007)
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