Currently browsing: “2006”

Eisosomes mark static sites of endocytosis

KEYWORDS: 2006 • Eisosomes • Endocytosis • eukaryotic cells • lipid clustering • Sebastián Bernales • signalling receptors

ABSTRACT: Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalize nutrients in all eukaryotic cells. Internalization of proteins, lipids and other cargo can occur by one of several pathways that have different, but often overlapping, molecular requirements1–5. To mediate endocytosis, effectors assemble transiently underneath the plasma membrane, carry out the […]

A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins

KEYWORDS: 2006 • Laboratory of Cellular and Molecular Immunology • Mario Rosemblatt • Piscirickettsia salmonis • Recombinant antigens • Recombinant proteins • Subunit vaccine

ABSTRACT: We report here the protective effect against piscirickettsiosis elicited in fish by a mixture of recombinant proteins. A comparative genomics strategy was used on a genomic library of Piscirickettsia salmonis in order to select optimal candidates for a recombinant subunit vaccine to protect fish from rickettsial septicaemia (SRS). Based on this information, 15 P. […]