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Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells

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ABSTRACT: Whereas naive T cells migrate only to secondary lymphoid organs¹˒², activation by antigen confers to T cells the ability to home to non-lymphoid sites³˒⁴. Activated effector/memory T cells migrate preferentially to tissues that are connected to the secondary lymphoid organs where antigen was first encountered⁵⁻⁷. Thus, oral antigens induce effector/memory cells that express essential […]

Mora J. R., Bono M. R., Manjunath N., Weninger W., Cavanagh L. L., Rosemblatt M. and Von Andrian U. H. Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells. Nature 424, 88-93 (2003)
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