Researh & development

Merken Biotech SPA

Profile

The group directed by Sebastián Bernales focuses in the identification of novel small molecules for the
modulation of potential targets on the Unfolded Protein Response (UPR) and the Integrated Stress
Response (ISR). In collaboration with Praxis Biotech (USA), they have designed and optimized potent
small molecules modulating signaling components of the UPR. By modulation of the ISR, they have
shown reversing of spatial memory deficits, in old mice. These results suggest that a pharmacological
interference with the ISR emerges as a promising intervention strategy for combating age-related
cognitive decline.

Telefono: 56 22 3672086
Correo electrónico: contacto@merkenbiotech.com

Research Assistants:

  • Claudia Acuña
  • Miguel Vargas
  • Ximena Castillo
  • Andrea Nettle
  • Benita Godoi
  • Constanza López
  • Denisse Mena
  • Macarena Muñoz
  • Alexandra Córdova
  • Ignacio Ávalos
  • Nicole Araya
  • Stephanie Cortez
  • Glenda Fuentealba
  • Tamara Rojas
  • Camila Aros
  • Carolina Deantas
  • Valentina Polanco
  • Katherine Stack Lara
  • Catalina Urra
  • Patricio González
  • Alison Gazitúa

Post-doctoral Fellows:

  • Jennifer Alfaro
  • Sebastian Belmar
  • Javier Guerrero
  • Gonzalo Ureta
  • Eduardo Riquelme
  • Luz Delgado
  • Yandi Rigual

  • Odette Ibañez
  • Francisca Guevara

National Collaborations

  • Medzyme
  • Connectomica (Fundación Ciencia & Vida)
  • Food for Future
  • Kura Biotech
  • Cellus Medicina regenerativa
  • Botanical Solutions
  • Inbio soluciones biotecnológicas
  • Thani Biotechnologies ( Dr. Carlos Fardella, UC)
  • Andes Biotechnologies

Internationals Collaborations

  • Dr. Peter Walter at UCSF (California, USA)
  • Dr. Mauro Costa-Mattioli at Baylor College of medicine (Houston, USA)
  • Dr. Susanna Rossi at UCSF (California, USA)
  • Dr. Siva Kolluri at Oregon State University (Oregon, USA)
  • Dr. Sergio Quezada at UCL (London, UK)
  • Metagenomi (California, USA)
  • Kirrhos Pharmaceuticals LLC (Oklahoma, USA)Black Belt TX Ltd (LondoGGn, UK)
  • Kreas, Inc.
  • Integral Biosciences (Noida, India)

Publications

Ansari A, Satalkar S, Patil V, Shete AS, Kaur S, Gupta A, Singh S, Raja M, Severance DL, Bernales S, Chakravarty S, Hung DT, Pham SM, Herrera FJ, Rai R. Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR. Bioorg Med Chem Lett. 2017 Jan 15;27 (2):217-222. doi: 10.1016/j.bmcl.2016.11.080.

Alfaro J, Pérez de Arce F, Belmar S, Fuentealba G, Avila P, Ureta G, Flores C, Acuña C, Delgado L, Gaete D, Pujala B, Barde A, Nayak AK, Upendra TVR, Patel D, Chauhan S, Sharma VK, Kanno S, Almirez RG, Hung DT, Chakravarty S, Rai R, Bernales S, Quinn KP, Pham SM, McCullagh E. Dual Inhibition of Bruton’s Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin’s B Cell Malignancies. J Pharmacol Exp Ther. 2017 May;361(2):312-321. doi: 10.1124/jpet.116.238022.

Krukowski K, Nolan A, Frias ES, Grue K, Becker M, Ureta G, Delgado L, Bernales S, Sohal VS, Walter P, Rosi S. Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma. J Neurotrauma. 2020 Jun 1;37(11):1370-1380. doi: 10.1089/neu.2019.6827.

Karen Krukowski, Amber Nolan, Elma S Frias, Morgane Boone, Gonzalo Ureta, Katherine Grue, Maria-Serena Paladini, Edward Elizarraras, Luz Delgado, Sebastian Bernales, Peter Walter, Susanna Rosi. Small molecule cognitive enhancer reverses age-related memory decline in mice. eLife. 2020; 9: e62048. Published online 2020 Dec 1. doi: 10.7554/eLife.62048

Mauricio M. Oliveira, Mychael V. Lourenco, Francesco Longo, Nicole P. Kasica, Wenzhong Yang, Gonzalo Ureta, Danielle D. P. Ferreira, Paulo H. J. Mendonça, Sebastian Bernales, Tao Ma, Fernanda G. De Felice, Eric Klann, Sergio T. Ferreira. “Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity and memory in mouse models of Alzheimer’s disease” Sci Signal. 2021 Feb 2; 14(668): eabc5429. Published online 2021 Feb 2. doi: 10.1126/scisignal.abc5429

Principal investigator

Sebastián Bernales

+56 2 2367 2086

sebastian.bernales@praxisbiotech.com

Biography

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