How do our cells sense and respond to internal and external signals? They use very sophisticated networks of molecules known as intracellular signaling pathways. These pathways are not only important for normal cells but also for cells that are at the center of disease conditions. Therefore, the pharmacological modulation of these networks could be a way to develop novel therapies to treat critically ill patients with diseases for which there are limited treatment options. Our lab, which is composed of a unique group of cell biologists, biochemists, pharmacologists and chemists, focuses on the validation and modification of known signaling pathways that can be involved in diseases. Our goal is to bring projects from the bench to the clinic and minimize the time to do so.