Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes

ABSTRACT

Background: Antisense mitochondrial ncRNAs are down-regulated during oncogenesis by unknown mechanisms.

Results: High risk HPV E2 oncogene induces down-regulation of the antisense transcripts. Additionally, E6 and E7 induce expression of a new sense mitochondrial ncRNA.

Conclusion: HPV oncogenes modulate expression of mitochondrial ncRNAs.

Significance: During non-viral oncogenesis, cellular factor(s), analogously to E2, could induce down-regulation of the antisense mitochondrial nc RNAs.