Currently browsing: “Publications”

Osorio-Barrios F., Prado C., Contreras F., Pacheco R. Dopamine receptor D5 signalling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favouring suppressive activity of regulatory T-cells. Front Cell Neurosci. 12(1): 192. doi: 10.3389/fncel.2018.00192 (2018).

Osorio-Barrios F., Prado C., Contreras F., Pacheco R. Dopamine receptor D5 signalling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favouring suppressive activity of regulatory T-cells. Front Cell Neurosci. 12(1): 192. doi: 10.3389/fncel.2018.00192 (2018).
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Prado C., Iruretagoyena M., Burgos P.I., Pacheco R. Tobacco promotes exacerbated inflammatory features in dendritic cells of Chilean rheumatoid arthritis patients. Rev Med Chil. 146(2): 150-159. doi: 10.4067/s0034-98872018000200150 (2018).

Prado C., Iruretagoyena M., Burgos P.I., Pacheco R. Tobacco promotes exacerbated inflammatory features in dendritic cells of Chilean rheumatoid arthritis patients. Rev Med Chil. 146(2): 150-159. doi: 10.4067/s0034-98872018000200150 (2018).
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Saavedra F., Gurard-Levin ZA., Rojas-Villalobos C., Vassias I., Quatrini R., Almouzni G., Loyola A. JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability. Epigenetics & Chromatin. 13:6. DOI: 10.1186/s13072-020-00331-1 (2020)

Saavedra F., Gurard-Levin ZA., Rojas-Villalobos C., Vassias I., Quatrini R., Almouzni G., Loyola A. JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability. Epigenetics & Chromatin. 13:6. DOI: 10.1186/s13072-020-00331-1 (2020)
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Flores-Rios R., Quatrini R., Loyola A. Endogenous and Foreign Nucleoid-Associated Proteins of Bacteria: occurrence, interactions and effects on Mobile Genetic Elements and host ́s biology. Computational and Structural Biotechnology Journal. 17: 746-756. DOI: https://doi.org/10.1016/j.csbj.2019.06.010 (2019)

Flores-Rios R., Quatrini R., Loyola A. Endogenous and Foreign Nucleoid-Associated Proteins of Bacteria: occurrence, interactions and effects on Mobile Genetic Elements and host ́s biology. Computational and Structural Biotechnology Journal. 17: 746-756. DOI: https://doi.org/10.1016/j.csbj.2019.06.010 (2019)
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Hernández S., Díaz A., Loyola A., Villanueva RA. Recombinant HCV NS3 and NS5b enzymes exhibit multiple posttranslational modifications for potential regulation. Virus Genes. 55 (2): 227-232. DOI: 10.1007/s11262-019-01638-2 (2019)

Hernández S., Díaz A., Loyola A., Villanueva RA. Recombinant HCV NS3 and NS5b enzymes exhibit multiple posttranslational modifications for potential regulation. Virus Genes. 55 (2): 227-232. DOI: 10.1007/s11262-019-01638-2 (2019)
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Saavedra F., Boyarchuk E., Alvarez F., Almouzni G., Loyola A. Metabolic deregulations affecting chromatin architecture: One-carbon metabolism and Krebs cycle impact histone methylation. In: The DNA, RNA, and Histone Methylomes, edited by S. Jurga and J. Barciszewski., vol 9. RNA TECHNOLOGIES, Springer Series (2019)

Saavedra F., Boyarchuk E., Alvarez F., Almouzni G., Loyola A. Metabolic deregulations affecting chromatin architecture: One-carbon metabolism and Krebs cycle impact histone methylation. In: The DNA, RNA, and Histone Methylomes, edited by S. Jurga and J. Barciszewski., vol 9. RNA TECHNOLOGIES, Springer Series (2019)
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Saavedra F., Marty-Lombardi S., Loyola A. Characterization of Posttranslational Modifications on Histone Variants”. In: Histone Variants. Methods in Molecular Biology, edited by G. Orsi G and G. Almouzni, vol 1832. Humana Press, New York, NY. DOI: 10.1007/978-1-4939-8663-7_2 (2018)

Saavedra F., Marty-Lombardi S., Loyola A. Characterization of Posttranslational Modifications on Histone Variants”. In: Histone Variants. Methods in Molecular Biology, edited by G. Orsi G and G. Almouzni, vol 1832. Humana Press, New York, NY. DOI: 10.1007/978-1-4939-8663-7_2 (2018)
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Bignon, EA, Albornoz, A, Guardado-Calvo, P, Rey, FA*, Tischler, ND* (2019). Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface. eLife e46028. doi: 10.7554/eLife.46028.

Bignon, EA, Albornoz, A, Guardado-Calvo, P, Rey, FA*, Tischler, ND* (2019). Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface. eLife e46028. doi: 10.7554/eLife.46028.
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El Omari, K, Li, S, Kotecha, A, Walter, TS; Bignon EA; Harlos, K; Somerharju, P; De Haas, F; Clare DK; Molin, M; Hurtado, F; Li, M; Grimes, JM; Bamford, DH; Tischler, ND*; Huiskonen, JT*; Stuart, DI*; Roine, E.* (2019). The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nature Com, 10(1):846. doi: 10.1038/s41467-019-08728-7.

El Omari, K, Li, S, Kotecha, A, Walter, TS; Bignon EA; Harlos, K; Somerharju, P; De Haas, F; Clare DK; Molin, M; Hurtado, F; Li, M; Grimes, JM; Bamford, DH; Tischler, ND*; Huiskonen, JT*; Stuart, DI*; Roine, E.* (2019). The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nature Com, 10(1):846. doi: 10.1038/s41467-019-08728-7.
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Jangra, RK; Herbert, AS; Li, R.; Jae, LT; Kleinfelter, LM; Slough, MM; Barker, SL; Guardado-Calvo, P; Román-Sosa, R; Dieterle, ME; Kuehne, AI; Muena, NA; Wirchnianski, AS; Nyakatura, EK; Fels, JM; Ng, M; Mittler, E; Pan, J.; Bharrhan, S; Wec, AZ; Lai, JR; Sidhu, SS; Tischler, ND; Rey, FA; Moffat, J; Brummelkamp, TR*; Wang, Z*; Dye, JM*; Chandran, K* (2018). Protocadherin-1 is critical for cell entry by New-World hantaviruses. Nature 563(7732):559-563. doi: 10.1038/s41586-018-0702-1.

Jangra, RK; Herbert, AS; Li, R.; Jae, LT; Kleinfelter, LM; Slough, MM; Barker, SL; Guardado-Calvo, P; Román-Sosa, R; Dieterle, ME; Kuehne, AI; Muena, NA; Wirchnianski, AS; Nyakatura, EK; Fels, JM; Ng, M; Mittler, E; Pan, J.; Bharrhan, S; Wec, AZ; Lai, JR; Sidhu, SS; Tischler, ND; Rey, FA; Moffat, J; Brummelkamp, TR*; Wang, Z*; Dye, JM*; Chandran, K* (2018). Protocadherin-1 is critical for cell entry by New-World hantaviruses. Nature 563(7732):559-563. doi: 10.1038/s41586-018-0702-1.
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Guardado-Calvo, P, Bignon, EA, Stettner, E, Jeffers SA, Pehau-Arnaudet, G, Tortorici, MA, Jestin, JL, England, P, Tischler, ND*, Rey, FA* (2016). Mechanistic insight into bunyavirus-induced membrane 1 fusion from structure-function analyses of the hantavirus envelope glycoprotein Gc. PLoS Path 12(10):e1005813. doi: 10.1371/journal.ppat.1005813.

Guardado-Calvo, P, Bignon, EA, Stettner, E, Jeffers SA, Pehau-Arnaudet, G, Tortorici, MA, Jestin, JL, England, P, Tischler, ND*, Rey, FA* (2016). Mechanistic insight into bunyavirus-induced membrane 1 fusion from structure-function analyses of the hantavirus envelope glycoprotein Gc. PLoS Path 12(10):e1005813. doi: 10.1371/journal.ppat.1005813.
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Willensky, S, Bar-Rogovsky, H, Bignon, EA, Tischler, ND, Modis, Y, Dessau, M* (2016). Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation. PLoS Path 12(10):e1005948. doi: 10.1371/journal.ppat.1005948.

Willensky, S, Bar-Rogovsky, H, Bignon, EA, Tischler, ND, Modis, Y, Dessau, M* (2016). Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation. PLoS Path 12(10):e1005948. doi: 10.1371/journal.ppat.1005948.
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Albornoz A, Hoffmann AB, Lozach PY, Tischler ND (2016). Early Bunyavirus-host cell interactions. Viruses 24;8(5). doi: 10.3390/v8050143.

Albornoz A, Hoffmann AB, Lozach PY, Tischler ND (2016). Early Bunyavirus-host cell interactions. Viruses 24;8(5). doi: 10.3390/v8050143.
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Barriga GP, Villalón-Letelier F, Márquez CL, Bignon EA, Acuña R, Ross BH, Monasterio O, Mardones GA, Vidal SE, Tischler ND (2016). Inhibition of the hantavirus fusion process by predicted domain III and stem peptides from glycoprotein Gc. PLoS Negl Trop Dis 10(7), e0004799. doi: 10.1371/journal.pntd.0004799

Barriga GP, Villalón-Letelier F, Márquez CL, Bignon EA, Acuña R, Ross BH, Monasterio O, Mardones GA, Vidal SE, Tischler ND (2016). Inhibition of the hantavirus fusion process by predicted domain III and stem peptides from glycoprotein Gc. PLoS Negl Trop Dis 10(7), e0004799. doi: 10.1371/journal.pntd.0004799
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Acuña R., Bignon E.A., Mancini R., Lozach P.Y., Tischler N.D. (2015). Acidification triggers Andes hantavirus membrane fusion and rearrangement of Gc into a stable post-fusion homotrimer. J Gen Virol. 96(11):3192-7. doi: 10.1099/jgv.0.000269

Acuña R., Bignon E.A., Mancini R., Lozach P.Y., Tischler N.D. (2015). Acidification triggers Andes hantavirus membrane fusion and rearrangement of Gc into a stable post-fusion homotrimer. J Gen Virol. 96(11):3192-7. doi: 10.1099/jgv.0.000269
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