Contreras, O., Soliman, H., Theret, M., Rossi, F.M., and Brandan, E. (2020) TGF--driven downregulation of the Wnt/b-Catenin transcription factor TCF7L2/TCF4 in PDGFRa+ fibroblasts. J. Cell Sci. 133(12):jcs242297. doi: 10.1242/jcs.242297

Elizabeth Rivas-Yáñez, Carlos Barrera-Avalos, Brian Parra-Tello, Pedro Briceño, Mariana V. Rosemblatt, Juan Saavedra-Almarza, Mario Rosemblatt, Claudio Acuña-Castillo, María Rosa Bono and Daniela Sauma. P2X7 receptor at the crossroads of T cell fate. Int. J. Mol. Sci. 2020, 21, 4937; doi:10.3390/ijms21144937.

Yessia Hidalgo, Sarah Núñez, Maria Jose Fuenzalida, Felipe Flores-Santibáñez, Pablo J. Sáez, Jessica Dorner, Ana-Maria Lennon-Dumenil, Victor Martínez, Emmanuel Zorn, Mario Rosemblatt, Daniela Sauma and Maria Rosa Bono. Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus Prone Mice. Front. Immunol. 11:696 (2020). doi:10.3389/fimmu.2020.00696.

Felipe Flores-Santibáñez, Bárbara Cuadra, Dominique Fernández, Mariana Rosemblatt, Sarah Núñez, Pablo Cruz, Felipe Gálvez-Cancino, J.César Cárdenas, Alvaro Lladser, Mario Rosemblatt, María Rosa Bono and Daniela Sauma. In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo. Frontiers in Immunology. 9:209. doi: 10.3389/fimmu.2018.00209 (2018).

Daniela Sauma, Natalia Crisóstomo, Camila Fuentes, María Alejandra Gleisner, Yessia Hidalgo, María José Fuenzalida, Mario Rosemblatt & María Rosa Bono. Adoptive transfer of autoimmune splenic dendritic cells
to lupus-prone mice triggers a B lymphocyte humoral response. Immunol Res. 65(4):957-968. doi: 10.1007/s12026-017-8936-9 (2017).

Valle-Tenney R, Rebolledo D, Acuña MJ, Brandan E. (2020) HIF-hypoxia signaling in skeletal muscle physiology and fibrosis. J Cell Commun Signal. 14: 147-158.

Valle-Tenney R, Rebolledo D, Lipson KE, Brandan E. (2019) Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. 87: 48-65.

Contreras, O., Cruz-Soca, M., Theret, M., Soliman, H., Groppa, H., Wei, L., , Rossi, F.M., and Brandan, E. (2019) TGF-β and PDGFRα signaling pathways cross-talk regulates stromal fibro/adipogenic progenitors’ differentiation. J. Cell Sci doi: 10.1242/jcs.232157

Contreras, O., Rossi, F.M., and Brandan, E. (2019) Adherent muscle connective tissue fibroblasts are phenotypically and biochemically equivalent to stromal fibro/adipogenic progenitors. Matrix Biol Plus doi.org/10.1016/j.mbplus.2019.04.003

Rebolledo, D.L., González, D., Faundez-Contreras, J., Contreras, O., Murphy-Ullrich, J.E., Lipson, K.E. and Brandan, E. (2019) CTGF/CCN2 Modulates Denervation-induced Skeletal Muscle Fibrosis independently of TGF- Matrix Biol. doi: 10.1016/j.matbio.2019.01.002

Gonzalez, D and Brandan, E (2019) CTGF/CCN2 from skeletal muscle to nervous system: impact on neurodegenerative diseases. Mol. Neurobiol. In Press doi.org/10.1007/s12035-019-1490-9

Gonzalez, D., Rebolledo, D.L., Correa, L.M., Court, F., Cerpa, W., Lipson, K.E. Zundert, B.V. and Brandan, E. (2018) The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum. Mol. Gen. 27: 2913-2926

Contreras, O., Villarreal, M. and Brandan, E. (2018) Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skeletal Muscle 20, 8(1):5. doi: 10.1186/s13395-018-0150-5

Riquelme-Guzmán, C., Contreras, O., and Brandan E. (2018) Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. Am. J. Physiol. Cell Physiol. 314: C415–C427.

Acuña, MJ., Salas, D., Cordova-Casanova, A., Cruz-Soca, A., Céspedes, C, Vío, C.P. and Brandan, E (2017) Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors. J Cell Commun Signal. doi: 10.1007/s12079-017-0439-x

Latest news

18/11/2021

Fundacion Ciencia & Vida participates in Puerto de Ideas

10/10/2021

Fundacion Ciencia & Vida participates at the 2021 Science Festival

8/09/2021

Fundacion Ciencia & Vida is awarded a provisional funding project through a “Centers of excellence support contest”