Currently browsing: “Publications”

Fine tuning assessment of research: The hKA index.

ABSTRACT: During the past few years, institutions, scientific academies and government funding offices have adopted the h-index (Hirsch, 2005) as a parameter to measure research achievement. Several groups have discussed the limitations of the h-index (Costas and Bordons, 2007; Lawrence, 2007; Qiu et al., 2008). However, none of them have considered if the person being analyzed is a […]

Krauskopf E. Fine tuning assessment of research: The hKA index. Proceedings of ISSI 2, 1010-1011 (2009)
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The HP1α-CAF-1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin

ABSTRACT: Trimethylation of lysine 9 in histone H3 (H3K9me3) enrichment is a characteristic of pericentric heterochromatin. The hypothesis of a stepwise mechanism to establish and maintain this mark during DNA replication suggests that newly synthesized histone H3 goes through an intermediate methylation state to become a substrate for the histone methyltransferase Suppressor of variegation 39 […]

Loyola A., Tagami H., Bonaldi T., Roche D., Quivy J. P., Imhof A., Nakatani Y., Dent S. Y. R., Almouzni G. The HP1α -CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep. 10(7): 769-775 (2009)
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Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells.

ABSTRACT: We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5′ end of the mitochondrial 16s RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, […]

Burzio V.A., Villota C., Villegas J., Landerer E., Boccardo E., Villa L.L, Martínez R., López C., Gaete F., Toro V., Rodriguez X. and Burzio L.O. Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells. PNAS 106 (23): 9430-9434 (2009)
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Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes

ABSTRACT: Testicular injuries like torsion or cryptorchidism can cause massive germ cell death, which could have great impact on male reproductive health. In addition, it has been proposed that modern life style, in the form of underwear or sedentary work position, could increase the testicular temperature, induce germ cell apoptosis, reduce spermatozoa quality and promote […]

Lizama C., Lagos C. F., Lagos-Cabré R., Cantuarias L., Rivera F., Huenchuñir P., Pérez-Acle T., Carrión F. and Moreno R. D. Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes. J. Cell. Physiol. 221 (2): 296-305 (2009)
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Matus S., Nassif M., Glimcher LH, and Hetz C. (2009). “XBP-1 deficiency in the nervous system revealed a homeostatic switch to activate autophagy”. Autophagy. Nov 6;5(8). (Cover illustration).

Matus S., Nassif M., Glimcher LH, and Hetz C. (2009). “XBP-1 deficiency in the nervous system revealed a homeostatic switch to activate autophagy”. Autophagy. Nov 6;5(8). (Cover illustration).
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Role of dopamine in the physiology of T cells and dendritic cells.

ABSTRACT: Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to […]

Pacheco R., Prado C. E., Barrientos M. J., Bernales S. Role of dopamine in the physiology of T-cells and dendritic cells. J. Neuroimmunol. 216 (1-2): 8-19 (2009)
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Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fcᵞ and costimulatory molecules on dendritic cells.

ABSTRACT: Dendritic cells (DCs) play a pivotal role in the interface between immunity and maintenance of peripheral tolerance. The capture of immunoglobulin G (IgG)-containing immune complexes (ICs) by low-affinity Fcᵞ receptors (FcᵞRs) expressed on DCs may influence the immunogenicity/tolerogenicity of these cells, depending on the activating/inhibitory potential of FcᵞRs. Because of the key role that […]

Carreño L. J., Pacheco R., Gutierrez M. A., Jacobelli S., Kalergis A. M. Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fcᵞ receptors and costimulatory molecules on dendritic cells. Immunology 128 (3): 334-341 (2009)
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Immunological dysfunction in HIV-1-infected individuals by impairment of adenosine deaminase-induced costimulation of T-Cell activation

ABSTRACT: The cell surface association between CD26 and adenosine deaminase (ADA) has a costimulatory function during T-cell activation. Several studies have revealed correlations among CD4+ CD26+ T-cell depletion, increased serum levels of ADA, and the evolution of human immunodeficiency virus (HIV) infection, implicating CD26 and ADA in HIV disease progression. In this context, we aimed […]

Martinez-Navio J. M., Climent N., Pacheco R., Garcia F., Plana M., Nomdedeu M., Oliva H., Rovira C., Miralles L., Gatell J. M., Gallart T., Mallol J., Lluis C. and Franco R. Immunological Dysfunction in HIV-1-Infected Individuals caused by Impairment of adenosine deaminase-induced costimulation of T-Cell activation. Immunology 128 (3): 393-404 (2009)
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Hetz C, Thielen P, Matus S., M Nassif, Court F., Cuervo AM., Martinez G., Kiffin R., R.H. Brown and Glimcher L. (2009). “XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy”. Genes & Dev. 23:2294–2306. (Cover illustration) *Commented in Genes Dev. (2009), 23:2294-306.

Hetz C, Thielen P, Matus S., M Nassif, Court F., Cuervo AM., Martinez G., Kiffin R., R.H. Brown and Glimcher L. (2009). “XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy”. Genes & Dev. 23:2294–2306. (Cover illustration) *Commented in Genes Dev. (2009), 23:2294-306.
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Una mirada epistemométrica de la Revista Médica de Chile y su aporte al conocimiento de la Medicina

ABSTRACT: During the last decade Revista Médica de Chile increased its visibility, measured on citations and impact factor. Aim: To perform a scientometric analysis to assess the performance of Revista Médica de Chile. Material and methods: Thomson’s-ISI Web of Science and Journal Citation Reports (JCR) were consulted for performance indicators of Revista Médica de Chile and Latin American journals […]

Krauskopf M. and Krauskopf E. Una Mirada epistemométrica de la Revista Médica de Chile y su aporte al conocimiento de la Medicina. Rev. Méd. Chile 136, 1065-1072 (2008)
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Generation and analysis of an Eucalyptus globulus cDNA library constructed from seedlings subjected to low temperature conditions

ABSTRACT: Eucalyptus globulus is the most important commercial temperate hardwood in the world because of its wood properties and due to its characteristics for biofuel production. However, only a very low number of expressed sequence tags (ESTs) are publicly available for this tree species. We constructed a cDNA from E. globulus seedlings subjected to low […]

Rasmussen-Poblete S., Valdes J., Gamboa M. C., Valenzuela P. D. T. and Krauskopf E. Generation and analysis of an Eucalyptus globulus cDNA library constructed from seedlings subjected to low temperature conditions. E. J. Biotechnology 11 (2): 01-13 (2008)
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Plant Science research productivity in Chile during the past 20 years

ABSTRACT: The purpose of this study was to carry out a bibliometric analysis of the articles published in Chile during 1987-2006  that were categorized into the Planet Science discipline by ISI. The data was extracted from the Web of Science database, obtaining a total of 911 articles for analysis. Almost half of the articles were […]

Krauskopf E. Plant Science research productivity in Chile during the past 20 years. Biol. Res. 41, 137-141 (2008)
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Computational modeling study of functional microdomains in cannabinoid receptor type 1

ABSTRACT: The seven transmembrane helices (TMH) G-protein-coupled receptors (GPCRs) constitute one of the largest superfamily of signaling proteins found in mammals. Some of its members, in which the cannabinoid (CB) receptors are included, stand out because their functional states can be modulated by a broad spectrum of effector molecules. The relative ligand promiscuity exhibited by […]

Gonzalez A., Duran Sepulveda L., Araya-Secchi R., Garate J. A., Pessoa-Mahana C. D., Lagos C. F. and Perez-Acle T. Computational modeling study of functional microdomains in cannabinoid receptor type 1. Bioorg. Med. Chem. 16 (8): 4378-4389 (2008)
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Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells

ABSTRACT: It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the gut-associated homing receptor CCR9. Thus, effector T cells generated after coculture with mesenteric lymph node […]

Elgueta R., Sepúlveda F. E., Vilches F., Vargas L., Mora J. R., Bono M. R. and Rosemblatt M. Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells. J. Immunol. 180, 6501-6507 (2008)
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Matus S., Lisbona F., Torres M., Leon C., Thielen P., and Hetz C. (2008). The stress rheostat: Interplay between the Unfolded Protein Response (UPR) and Autophagy in neurodegeneration. Curr. Mol. Med. 8:157-172. #.

Matus S., Lisbona F., Torres M., Leon C., Thielen P., and Hetz C. (2008). The stress rheostat: Interplay between the Unfolded Protein Response (UPR) and Autophagy in neurodegeneration. Curr. Mol. Med. 8:157-172. #.
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