Currently browsing: “Publications”

Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells

ABSTRACT: Background. We have previously shown a differential expression of a family of mitochondrial ncRNAs in normal and cancer cells. Normal proliferating cells and cancer cells express the sense mitochondrial ncRNA (SncmtRNA). In addition, while normal proliferating cells express two antisense mitochondrial ncRNAs (ASncmtRNAs-1 and 2), these transcripts seem to be universally down-regulated in cancer cells. […]

Landerer E., Villegas J., Burzio A. V., Oliveira L., Villota C., López C., Restovic F., Martínez R., Castillo O. and Burzio L. O. Nuclear localization of the mitochindrial ncRNAs in normal and cancer cells. Cell. Oncol. 34, 297-305 (2011)
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Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation

ABSTRACT: Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β’ and interleukin (IL) […]

Moore C., Fuentes C., Sauma D., Morales J., Bono M. R., Rosemblatt M. and Fierro J. A. Retinoic acid generates regulatory T cells in experimental transplantation. Transplant. Proc. 43 (6): 2334-2337 (2011)
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Differential regulation of notch ligands in dendritic cells upon interaction with T helper cells

ABSTRACT: The Notch signalling pathway has recently been linked to T helper 1 (Th1) / T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting cells. However, whether stimuli other than pathogen-derived factors are involved in the regulation of Notch ligand expression in dendritic cells […]

Sauma D., Espejo P., Ramirez A., Fierro A., Rosemblatt M. and Bono M. R. Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells. Scand. J. Immunol. 74, 62-70 (2011)
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MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

ABSTRACT: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting Cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. METHODS: […]

Villablanca E. J., Wang S., De Calisto J., Gomes D. C. O., Kane M. A., Napoli J. L., Blaner W. S., Kagechika H., Blomhoff R., Rosemblatt M., Bono M. R., Von Andrian U. H. and Mora J. R. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of Dendritic cells. Gastroenterology 141, 176-185 (2011)
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Matus S., Glimcher LH., and Hetz C. (2011). “Protein folding stress in neurodegenerative diseases: a glimpse into the ER”. Curr Op. Cell Biol. 23:239-52.

Matus S., Glimcher LH., and Hetz C. (2011). “Protein folding stress in neurodegenerative diseases: a glimpse into the ER”. Curr Op. Cell Biol. 23:239-52.
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Uniaxial magnetic anisotropy energy of fe wires embedded in carbon nanotubes

ABSTRACT: In this work, we analyze the magnetic anisotropy energy (MAE) of Fe cylinders embedded within zigzag carbon nanotubes, by means of ab initio calculations. To see the influence of the confinement, we fix the Fe cylinder diameter and we follow the changes of the MAE as a function of the diameter of the nanotube, […]

Muñoz F., Mejía-López J., Pérez-Acle T. and Romero A. H. Uniaxial magnetic anisotropy energy of fe wires embedded in carbon nanotubes. ACS Nano. 4 (5): 2883-2891 (2010)
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Giorgetti M, Gibbons JA, Bernales S, Alfaro IE, Drieu La Rochelle C, Cremers T, Altar CA, Wronski R, Hutter-Paier B, Protter AA. (2010) Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J Pharmacol Exp Ther. 333(3):748-57.

Giorgetti M, Gibbons JA, Bernales S, Alfaro IE, Drieu La Rochelle C, Cremers T, Altar CA, Wronski R, Hutter-Paier B, Protter AA. (2010) Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J Pharmacol Exp Ther. 333(3):748-57.
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Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus

ABSTRACT: Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to antinuclear Ab production. To identify gene intervals within Nba2 that control the development of autoantibody-producing B cells […]

Jorgensen T. N., Alfaro J., Enriquez H. L., Jiang C., Loo W. M., Atencio S., Bupp M. R., Mailloux C. M., Metzger T., Flannery S., Rozzo S. J., Kotzin B. L., Rosemblatt M., Bono M. R. and Erickson L. D. Development of murine lupus involves the combined genetic contribution of the SLAM and FcyR intervals within the Nba2 autoimmune susceptibility locus. The J. Immunol. 15, 775-786 (2010)
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Nassif M, Matus S, Castillo K, and Hetz C. (2010). “Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway”. Antiox Red. Sig, 13:1955-89.

Nassif M, Matus S, Castillo K, and Hetz C. (2010). “Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway”. Antiox Red. Sig, 13:1955-89.
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Varela-Nallar L, Alfaro IE, Serrano FG, Parodi J, Inestrosa NC. (2010) Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc Natl Acad Sci USA. 107(49):21164-9.

Varela-Nallar L, Alfaro IE, Serrano FG, Parodi J, Inestrosa NC. (2010) Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc Natl Acad Sci USA. 107(49):21164-9.
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Role of dopamine in the physiology of T-cells and dendritic cells

Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to the […]

Pacheco R., Prado C. E., Barrientos M. J., Bernales S. (2009). Role of dopamine in the physiology of T-cells and dendritic cells. Journal of Neuroimmunology, 216, 8-19.
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Extending the models for iron and sulfur oxidation in the extreme acidophile

Quatrini R., Appia-Ayme C., Denis Y., Jedlicki E., Holmes D. S., Bonnefoy V. Extending the models for iron and sulfur oxidation in the extreme acidophils. Acidithiobacillus ferrooxidans. BMC Genomics, 10:394 (2009) doi: 10.1186/1471-2164-10-394.
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Ribosomal internal transcribed spacer 2 (ITS2) exhibits a common core of secondary structure in vertebrates and yeast

ABSTRACT: Molecular mechanisms of ITS2 processing, a eukaryotic insertion between the 5.8S and LSU rRNA, remain largely elusive even in yeast. To delineate ITS2 structural and functional features which could be common to eukaryotes, we first produced phylogenetically supported folding models in the vertebrate lineage, then tested them in deeper branching and, more particularly, among […]

Joseph N., Krauskopf E., Vera M. I. and Michot B. Ribosomal internal transcribed spacer 2 (ITS2) exhibits a common core of secondary structure invertebrates and yeast. Nucleic Acids Res. 27 (23): 4533-4540 (2009)
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Latin American citation of Revista Médica de Chile – A reply

ABSTRACT:  Sr. Editor : El importante aporte de Krauskopf M y Krauskopf E “Una mirada epistemométrica de la Revista Médica de Chile y su aporte al conocimiento en Medicina”, justifica la relevancia de la revista a través de indicadores de impacto como los proporcionados por el Web of Science, Journal Citation Reports y SCImago Research. […]

Krauskopf M. and Krauskopf E. Latin American citation of Revista Médica de Chile – A reply. Rev. Méd. Chile 137 (2): 312-314 (2009)
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Making friends in High Places? Astronomy and Geophysics

ABSTRACT: In July an important decision was made by the board of the Thirty Meter Telescope Observatory, selecting Mauna Kea in Hawaii as the site for the construction of the TMT, rather than Cerro Armazones in Chile. The announcement was made in IYA2009, 400 years after the invention of the telescope, a device that has […]

Krauskopf E. Making friends in High Places? A. & G. 50 (6): 612 (2009)
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