Currently browsing: “Publications”

Quintanilla RA, Godoy JA, Alfaro IE, Cabezas D, Von Bernhardi R, Bronfman M, Inestrosa NC (2013) Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway. PLoS One. 8(5):e65140. doi: 10.1371/journal.pone.0065140.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. (2012) Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model. Mol. Psychiatry. 31 Jul 2012, doi: 10.1038/mp.2012.106.

Matus S, Castillo K, Hetz C. (2012). “Hormesis: protecting neurons against cellular stress in Parkinson disease”. Autophagy. Jun;8(6):997-1001.

Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes.

ABSTRACT: The study of RNA and DNA oncogenic viruses has proved invaluable in the discovery of key cellular pathways that are rendered dysfunctional during cancer progression. An example is high risk human papillomavirus (HPV), the etiological agent of cervical cancer. The role of HPV oncogenes in cellular immortalization and transformation has been extensively investigated. We […]

Host immunity during Respiratory Syncytial Virus pathogenesis

ABSTRACT: Infection by respiratory syncytial virus (RSV) is the leading cause of childhood hospitalization as well as a major health and economic burden worldwide. Unfortunately, RSV infection provides only limited immune protection to reinfection, mostly due to inadequate immunological memory, which leads to an exacerbated inflammatory response in the respiratory tract promoting airway damage during […]

Enzymatic and Extraenzymatic Role of Adenosine Deaminase 1 in T-Cell–Dendritic Cell Contacts and in Alterations of the Immune Function

ABSTRACT: Adenosine deaminase 1 (ADA1) is an enzyme of the purine metabolism whose congenital defect leads to severe combined immunodeficiency (SCID)[[AU: OK?]]. Although classically considered a cytosolic enzyme, early evidence from work in brain synaptosomes suggested that the enzyme could be an ectoenzyme. In lymphoid cells, ectoenzymatic activity of ADA1 was also found. The obvious […]

Role of CD26-adenosine deaminase interaction in the T cell-mediated immunity

ABSTRACT: CD26 is a 110 kDa surface-bound ectopeptidase with intrinsic dipeptidyl peptidase IV (DPP IV) activity, which binds ade- nosine deaminase (ADA) on the surface of T cells. ADA is an enzyme of the purine metabolism that has been the object of consi- derable interest mainly because the congenital defect causes severe combined immunodeficiency (SCID). […]

Hemocyanin of the molluskan concholepas concholepas exhibits an unusual heterodecameric array of subunits

ABSTRACT: We describe here the structure of the hemocyanin from the Chilean gastropod Concholepas concholepas (CCH), emphasizing some attributes that make it interesting among molluscan hemocyanins. CCH exhibits a predominant didecameric structure as revealed by electron microscopy and a size of 8 MDa by gel filtration, and, in contrast with other mollusc hemocyanins, its stabilization […]

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S. (2012) Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Mol Psychiatry. 7 August 2012, doi: 10.1038/mp.2012.115.

Gupta S, Read DE, Deepti A, Cawley K, Gupta A, Oommen D, Verfaillie T, Matus S, Smith MA, Mott JL, Agostinis P, Hetz C, Samali A. (2012). “Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis”. Cell Death Dis. 2012 Jun 28;3:e333.

The unforeseen impact of meeting abstracts on cancer research

ABSTRACT: The dissemination of scientific information usually occurs through peer-reviewed journals. Nevertheless, scientific conferences have shown to be an instance for researchers to communicate their results, obtaining immediate feedback on their findings. Yet, some researchers disregard the information presented at these conferences simply because it has not gone through a peer review process [1]. Therefore, […]

Sequential establishment of marks on soluble histones H3 and H4

ABSTRACT: Much progress has been made concerning histone function in the nucleus; however, following their synthesis, how their marking and subcellular trafficking are regulated remains to be explored. To gain an insight into these issues, we focused on soluble histones and analyzed endogenous and tagged H3 histones in parallel. We distinguished six complexes that we could […]

Molecular basis of ligand dissociation in β-adrenergic receptors

ABSTRACT: The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand binding/unbinding events is essential to understand the pharmacological properties of these G protein-coupled receptors. In this study, we use the steered molecular dynamics […]

Adenosine deaminase potentiates the generation of effector, memory and regulatory CD4+ T-cells.

ABSTRACT: By interacting with CD26 on the CD4+ T cell surface and with the AdoR A2B on the DC surface, ADA triggers a costimulatory signal for human T cells. The aim of this study was to know whether ADA-mediated costimulation plays a role in the differentiation of T cells. The results show that irrespective of […]

Bchex a virulence gen of Botrytis cinerea: characterization and functional analyses.

ABSTRACT: We previously identified Bchex as a highly expressed gene during filamentous growth in Botrytis cinerea. The gene encodes the principal protein of the Woronin body and has been shown to seal septal pores in response to cellular damage. In the present study, Southern blot analysis of genomic DNA indicated that the gene exists as […]