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The dopaminergic system in autoimmune diseases. Frontiers in Immunology

ABSTRACT: Bidirectional interactions between the immune and the nervous system sare of considerable interest both for deciphering their functioning and for designing novel therapeutic strategies. The past decade has brough taburs to finsights into the molecular mechanisms involvedin neuroimmune communications mediated by dopamine. Studies of dendritic cells (DCs) revealed that they express the whole machinery […]

Pacheco R., Contreras F. and Zouali M. The dopaminergic system in autoimmune diseases. Frontiers in Immunology. 5: 117. (2014)
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Trichostatin A promotes the generation and suppressive functions of regulatory T cells

Abstract: Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through differentiation of na¨ıve CD4+ T cells. The forkhead box P3 transcription factor (Foxp3) is a crucial molecule […]

Doñas C., Fritz M., Manríquez V., Tejón G., Bono M. R., Loyola A., Rosemblatt M. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin. Dev. Immunol 2013, 679804 (2013)
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On the thermodynamics of carbon nanotube single-file water loading: free energy, energy and entropy calculations

ABSTRACT: Single-file water chains confined in carbon nanotubes have been extensively studied using molecular dynamics simulations. Specifically, the pore loading process of periodic (6,6) and (5,5) single-walled carbon nanotubes was thermodynamically characterized by means of free-energy calculations at every loading state and compared to bulk water employing thermodynamic cycles. Long simulations of each end-state allowed […]

Garate J.A., Perez-Acle T., Oostenbrink C. On the thermodynamics of carbon nanotube single-file water loading: free energy, energy and entropy calculations. Phys Chem Chem Phys. 16(11):5119-5128. (2014)
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Human Papillomavirus and non-coding RNAs: from basics to diagnostic

ABSTRACT: Human Papillomavirus (HPV) is the etiological agent of cervical cancer. Like other oncogenic viruses HPV encode oncoproteins and the role of HPV oncogenes in cellular immortalization and transformation has been extensively investigated. HPV E6 and E7 proteins disable tumor suppressors p53 and Rb and up-regulate telomerase, fundamental changes for cell immortalization. Another important step […]

Villota C., Cifuentes-Muñoz N., Burzio L.O. Human Papillomavirus and non-coding RNAs: from basics to diagnostic. (2014)
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Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes

ABSTRACT Background: Antisense mitochondrial ncRNAs are down-regulated during oncogenesis by unknown mechanisms. Results: High risk HPV E2 oncogene induces down-regulation of the antisense transcripts. Additionally, E6 and E7 induce expression of a new sense mitochondrial ncRNA. Conclusion: HPV oncogenes modulate expression of mitochondrial ncRNAs. Significance: During non-viral oncogenesis, cellular factor(s), analogously to E2, could induce […]

Villota C, América Campos A, Soledad Vidaurre S, Oliveira-Cruz L, Boccardo E, Burzio V, Varas M, Villegas J, Villa L, Valenzuela PD, Socias M, Roberts S, Burzio L.O. Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes. The Journal of Biological Chemistry, vol. 287. 25, pp. 21303–21315. (2012)
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The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma

ABSTRACT Background: Cervical cancer is the third most common disease and the fourth leading cause of death in female’s worldwide. Treatment of this disease is successful when detection is at early neoplasic stages. Hence, multiple efforts have been pursued for early detection of cervical neoplasia. The aim of this study was to analyze the differential […]

Villegas J, Dadlan K, Ávila R, Villota C, Burzio V, López C, Socias M, Zapata L,Burzio L.O. The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma. Cancer Science & Therapy, S7 (2013).
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Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer

ABSTRACT Background: Bladder cancer is a significant cause of morbidity and mortality with a high recurrence rate. Early detection of bladder cancer is essential in order to remove the tumor, to preserve the organ and to avoid metastasis. The aim of this study was to analyze the differential expression of mitochondrial non-coding RNAs (sense and […]

Rivas A, Burzio V, Landerer E, Borgna V, Gatica S, Ávila R, López C, Villota C, De la Fuente R, Echenique J, Burzio L.O.Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer. BMC Urology, 12:37 (2012)
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Matus S. Medina D and Hetz C. (2014) “Common Ground: Stem Cell Approaches Find Shared Pathways Underlying ALS”. Cell Stem Cell. 2014. 14: 697-699.

Matus S. Medina D and Hetz C. (2014) “Common Ground: Stem Cell Approaches Find Shared Pathways Underlying ALS”. Cell Stem Cell. 2014. 14: 697-699.
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Nassif M., Valenzuela V., Rojas-Rivera D., Vidal R., Matus S., Castillo K., Fuentealba Y., Kroemer G., Levine B. and Hetz C. (2014) “Pathogenic role of Beclin 1/BECN1 in the development of amyotrophic lateral sclerosis” Autophagy. 2014 10:7,1-16.

Nassif M., Valenzuela V., Rojas-Rivera D., Vidal R., Matus S., Castillo K., Fuentealba Y., Kroemer G., Levine B. and Hetz C. (2014) "Pathogenic role of Beclin 1/BECN1 in the development of amyotrophic lateral sclerosis" Autophagy. 2014 10:7,1-16.
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Draft Genome Sequence of the Nominated Type Strain of “Ferrovum myxofaciens,” an Acidophilic, Iron-Oxidizing Betaproteobacterium.

Moya-Beltrán A, Cárdenas JP, Covarrubias PC, Issotta F, Ossandon FJ, Grail BM, Holmes DS, Quatrini R, Johnson DB. Draft Genome Sequence of the Nominated Type Strain of "Ferrovum myxofaciens," an Acidophilic, Iron-Oxidizing Betaproteobacterium. Genome Announc. 2, e00834-14 (2014) doi: 10.1128/genomeA.00834-14.
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Cochrane DR, Bernales S, Jacobsen BM, Cittelly DM, Howe EN, D’Amato NC, Spoelstra NS, Edgerton SM, Jean A, Guerrero J, Gómez F, Medicherla S, Alfaro IE, McCullagh E, Jedlicka P, Torkko KC, Thor AD, Elias AD, Protter AA, Richer JK (2014) Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res. 16(1):R7.

Cochrane DR, Bernales S, Jacobsen BM, Cittelly DM, Howe EN, D'Amato NC, Spoelstra NS, Edgerton SM, Jean A, Guerrero J, Gómez F, Medicherla S, Alfaro IE, McCullagh E, Jedlicka P, Torkko KC, Thor AD, Elias AD, Protter AA, Richer JK (2014) Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res. 16(1):R7.
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Matus S., Valenzuela V., Hetz, C. (2014). “A new method to measure of autophagy flux in the nervous system”. Autophagy. 2014 10(4):710-714.

Matus S., Valenzuela V., Hetz, C. (2014). “A new method to measure of autophagy flux in the nervous system”. Autophagy. 2014 10(4):710-714.
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Architecture and Gene Repertoire of the Flexible Genome of the Extreme Acidophile Acidithiobacillus caldus.

Acuña LG, Cárdenas JP, Covarrubias PC, Haristoy JJ, Flores R, Nuñez H, Riadi G, Shmaryahu A, Valdés J, Dopson M, Rawlings DE, Banfield JF, Holmes DS, Quatrini R. Architecture and Gene Repertoire of the Flexible Genome of the Extreme Acidophile Acidithiobacillus caldus. PLoS One. 8, e78237 (2013) doi: 10.1371/journal.pone. 0078237.
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Matus S., Valenzuela V, Medinas D, Hetz, C. (2013). “New insights about the role of ER stress in ALS”. Int J Cell Biol. 2013:674751. Review.

Matus S., Valenzuela V, Medinas D, Hetz, C. (2013). “New insights about the role of ER stress in ALS”. Int J Cell Biol. 2013:674751. Review.
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Trichostatin A promotes the differentiation and suppressive functions of regulatory T cells.

Doñas C., Fritz M., Manríquez V., Tejón G., Bono M. R., Loyola A., Rosemblatt M. Trichostatin A promotes the differentiation and suppressive functions of regulatory T cells. Clin. Dev. Immunol 2013, 679804 (2013)
[↓] PDF [+] More Information