Currently browsing: “Publications”

Purinergic signaling as a regulator of Th17 cell plasticity

Fernández D., Flores-Santibáñez F., Neira J., Osorio F., Tejón G., Núñez S., Hidalgo Y., Fuenzalida M. J., Meza D., Ureta G., Lladser A., Pacheco R., Acuña-Castillo C., Guixé V., Quintana F. J., Bono M. R., Rosemblatt M., Sauma D. Purinergic signaling as a regulator of Th17 cell plasticity. PloS ONE 11(6): e0157889 (2016)
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Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory

Moraga-Amaro R., González H., Ugalde V., Donoso-Ramos J. P., Quintana-Donoso D., Lara M., Morales B., Rojas P., Pacheco R., Stehberg J. Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory. Neuropharmacol. 103: 222-235 (2016)
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Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4+ T-cell activation and dendritic cell maturation.

Oliva H., Pacheco R., Rodríguez-García M., Naranjo-Gómez M., Climent N., Martínez-Navio J. M., Gil C., Plana M., García F., Miró J. M., Franco R., Borras F., Navaratnam N., Gatell J. M., Gallart T. Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4+ T-cell activation and dendritic cell maturation. Immunol. Cell Biol. doi: 10.1038/icb.2016.28 (2016)
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Regulation of the neurodegenerative process associated to Parkinson’s disease by CD4+ T-cells.

González H., Contreras F., Pacheco R. Regulation of the neurodegenerative process associated to Parkinson's disease by CD4+ T-cells. J. Neuroimmune Pharmacol. 10(4): 561-575 (2015)
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Dopamine receptors D3 and D5 regulate CD4 +T-cell activation and differentiation by modulating ERK activation and cAMP production.

Franz D., Contreras F., González H., Prado C., Elgueta D., Figueroa C., Pacheco R. Dopamine receptors D3 and D5 regulate CD4 +T-cell activation and differentiation by modulating ERK activation and cAMP production. J. Neuroimmunol. 284: 18-29 (2015)
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Jadhavara PS, Ramachandrana SA, Riquelme E, Guptaa A, Quinnc KP, Shivakumard D, Rayd S, Zendea D, Nayaka AK, Miglania SK, Sathea BD, Rajaa M, Farias O, Alfaro IE, Belmar S, Guerrero J, Bernales S, Chakravartyc S, Hung DT, Lindquist JN, Raic R (2016). Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. Bioorg Med Chem Lett. 26(21):5222-5228.

Jadhavara PS, Ramachandrana SA, Riquelme E, Guptaa A, Quinnc KP, Shivakumard D, Rayd S, Zendea D, Nayaka AK, Miglania SK, Sathea BD, Rajaa M, Farias O, Alfaro IE, Belmar S, Guerrero J, Bernales S, Chakravartyc S, Hung DT, Lindquist JN, Raic R (2016). Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. Bioorg Med Chem Lett. 26(21):5222-5228.
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Dopamine receptor D3 signaling on CD4+ T cells favors Th1- and Th17-mediated immunity

Contreras F., Prado C., González H., Franz D., Osorio-Barrios F., Osorio F., Ugalde V., Lopez E., Elgueta D., Figueroa A., Lladser A., Pacheco R. Dopamine receptor D3 signaling on CD4+ T cells favors Th1- and Th17-mediated immunity. J. Immunol. 196(10):4143 (2016)
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Jadhavar PS, Ramachandran SA, Riquelme E, Gupta A, Quinn KP, Shivakumar D, Ray S, Zende D, Nayak AK, Miglani SK, Sathe BD, Raja M, Farias O, Alfaro I, Belmar S, Guerrero J, Bernales S, Chakravarty S, Hung DT, Lindquist JN, Rai R. Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228. doi: 10.1016/j.bmcl.2016.09.058. Epub 2016 Oct 4. PubMed PMID: 27717544.

Jadhavar PS, Ramachandran SA, Riquelme E, Gupta A, Quinn KP, Shivakumar D, Ray S, Zende D, Nayak AK, Miglani SK, Sathe BD, Raja M, Farias O, Alfaro I, Belmar S, Guerrero J, Bernales S, Chakravarty S, Hung DT, Lindquist JN, Rai R. Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228. doi: 10.1016/j.bmcl.2016.09.058. Epub 2016 Oct 4. PubMed PMID: 27717544.
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Coexpressed catalase protects chimeric antigen receptor-redirected T cells as well as bystander cells from oxidative stress-induced loss of antitumor activity

Ligtenberg M. A., Mougiakakos D., Mukhopadhyay M., Witt K., Lladser A., Chmielewski M., Riet T., Abken H., Kiessling R. Coexpressed catalase protects chimeric antigen receptor-redirected T cells as well as bystander cells from oxidative stress-induced loss of antitumor activity. J. Immunol. 196(2):759 (2016)
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Bargsted L., Hetz C., Matus S. “ERp57 in neurodegeneration and regeneration”. Neural Regen Res. (2016) Feb;11(2):232-3.

Bargsted L., Hetz C., Matus S. “ERp57 in neurodegeneration and regeneration”. Neural Regen Res. (2016) Feb;11(2):232-3.
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Klionsky D.J., et al. “Guidelines for the use and interpretation of assays for monitoring autophagy” 3rd (edition). Autophagy. 2016;12(1):1-222.

Klionsky D.J., et al. “Guidelines for the use and interpretation of assays for monitoring autophagy” 3rd (edition). Autophagy. 2016;12(1):1-222.
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Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32. J Biol Chem.

Brennan MJ, Karcz J, Vaughn NR, Woolwine-Cunningham Y, DePriest AD, Escalona Y, Perez-Acle T, Skerrett IM. Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32. J Biol Chem. 2015 May 12. pii: jbc.M115.650747
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Towards bio-silicon interfaces: formation of an ultra-thin self-hydrated artificial membrane composed of dipalmitoylphosphatidylcholine (DPPC) and chitosan deposited in high vacuum from the gas-phase. J Chem Phys.

Retamal MJ, Cisternas MA, Gutierrez-Maldonado SE, Perez-Acle T, Seifert B, Busch M, Huber P, Volkmann UG. Towards bio-silicon interfaces: formation of an ultra-thin self-hydrated artificial membrane composed of dipalmitoylphosphatidylcholine (DPPC) and chitosan deposited in high vacuum from the gas-phase. J Chem Phys. 2014 Sep 14;141(10):104201. doi: 10.1063/1.4894224.
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Characterization of a novel water pocket inside the human Cx26 hemichannel structure.

Araya-Secchi R, Perez-Acle T, Kang SG, Huynh T, Bernardin A, Escalona Y, Garate JA, Martínez AD, García IE, Sáez JC, Zhou R. Characterization of a novel water pocket inside the human Cx26 hemichannel structure. Biophys J. 2014 Aug 5;107(3):599-612. doi: 10.1016/j.bpj.2014.05.037.
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Metagenomic Analysis Reveals Adaptations to a Cold Adapted Lifestyle in a Low Temperature Acid Mine Drainage Stream. FEMS Microbiol Ecol.

Maria Liljeqvist, Francisco J. Ossandon, Carolina Gonzalez, Sukithar Rajan, Adam Stell, Jorge Valdes, David S. Holmes and Mark Dopson. Metagenomic Analysis Reveals Adaptations to a Cold Adapted Lifestyle in a Low Temperature Acid Mine Drainage Stream. FEMS Microbiol Ecol. 2015 Jan 27. pii: fiv011. [Epub ahead of print].
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